Transcriptomic analysis of the innate immune signatures of a SARS-CoV-2 protein subunit vaccine ZF2001 and an mRNA vaccine RRVSARS-CoV-2 단백질 소단위 백신 ZF2001 및 mRNA 백신 RRV의 타고난 면역 특징의 전사체 분석Article Published on 2022-12-012022-09-11 Journal: Emerging Microbes & Infections [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation Analysis Anti-viral antibody approach binding CD74 Cell comparable COVID-19 cytokine Cytokines early response elicited expression level expression of gene framework Gene Expression Genes immune response immune responses immunization innate immune innate immune response Innate immunity involved mapped MHC class mRNA mRNA vaccine neutralization Neutralization antibody Pattern recognition pattern recognition receptor Pattern recognition receptors post vaccination Protein subunit protein subunit vaccine PRRs RNA degradation robust SARS-CoV-2 SARS-CoV-2 protein subunit Subunit vaccine Tap1 titre titres Transcription transcriptional Transcriptome transcriptome sequencing Transcriptome sequencing. transcriptomic transduction Vaccine ZF2001 [DOI] 10.1080/22221751.2022.2059404 PMC 바로가기 [Article Type] Article
Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaquesSARS-CoV-2 초기 감염된 붉은털 원숭이의 여러 기관의 차등 전사체 풍경Article Published on 2022-12-012022-09-11 Journal: Protein & Cell [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] accompanied analyzed Angiogenesis cause Central nervous system cerebral cortex changes in clinical complications clinical manifestation clinical manifestations CNS Coagulation controls drastic dysregulation early infection elevated Encephalitis evidenced examined exhibited expression expressions Factor fibrosis function Genes hyperinflammatory state immune response immune responses infected with SARS-CoV-2 Infection Inflammation inflammation response Inflammatory factor inflammatory factors mechanism multiple organ neuropilin 1 NRP1 organs positive positive feedback post infection provide receptor rhesus rhesus macaque right ventricle SARS-CoV-2 SARS-COV-2 infection significantly tissue tissues transcriptomic transcriptomic alteration Transmission up-regulated upregulation Viral viral encephalitis viral encephalitis. [DOI] 10.1007/s13238-022-00915-5 PMC 바로가기 [Article Type] Article
Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infectionArticle Published on 2022-11-012022-11-15 Journal: Journal of medical virology [Category] COVID19(2023년), SARS, 유전자 메커니즘, 진단, [키워드] Activation acute respiratory syndrome alteration analysis antibody production Apoptosis B cell caused collected CoronaVac coronavirus COVID-19 COVID-19 infected patient COVID-19 patients COVID-19 vaccine cytotoxicity downregulation Emergency use authorization expression expression of gene feature greater HLA class II IL21R immune Immune cell immune cell types immune response immunization immunized immunological Immunological response immunological responses inactivated Inactivated vaccine individual individuals Infection Inflammatory cytokine innate immune cell interferon response magnitude mechanism Migration mononuclear cells naïve B cell naïve B cells pandemic PBMC Peripheral blood phenotype plasma profile Proinflammatory cytokine proportion provide reveal SARS-CoV-2 SARS-COV-2 infection scRNA-seq Sequencing severe disease single-cell Single-cell RNA sequencing single-cell sequencing. Sinovac systemic immune response T cell thrombosis transcriptomic upregulation vaccine-induced immune response [DOI] 10.1002/jmv.28012 PMC 바로가기
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial CellsArticle Published on 2022-10-262022-11-15 Journal: Microbiology Spectrum [Category] COVID19(2023년), SARS, 변종, 유전자 메커니즘, 치료제, [키워드] Activation Adaptive immune response association biochemical Caco2 caused changed chemokine Colon contributed COVID-19 cytokine declining Delta delta variant disease epithelial cell line evade Evolution expected fatality feature highlighting Host Human humans IFN IFN response Infection Innate innate antiviral innate immune response interferon Intervention mechanism multiple mechanism outcome pandemic pathophysiology pathway persistence receptor reduced Replication response resulting RLR pathway robust SARS-CoV-2 SARS-CoV-2 variant severe disease Severe infection severe symptom silent susceptible sustained the disease transcriptomic Treatment vaccination variant variants variants. viral evolution virulence virus with COVID-19 [DOI] 10.1128/spectrum.01604-22 PMC 바로가기
Early suppression of antiviral host response and protocadherins by SARS-CoV-2 Spike protein in THP-1-derived macrophage-like cellsArticle Published on 2022-10-202022-11-15 Journal: Frontiers in Immunology [Category] COVID19(2023년), SARS, 치료제, [키워드] acute respiratory syndrome Alpha Antiviral approved Cell cells cellular cellular response change coronavirus Coronavirus disease-19 COVID-19 cytokine differentially expressed downregulation Effect effort expressing expression highlight homeostasis host cells host response humoral immune responses induce Infection information interferon intrinsic involved medium pandemic pathogenic PROTECT Protein reflected Result S protein SARS-CoV-2 spike Spike protein the S protein transcriptomic transcriptomics transcriptomics. type I Vaccination strategies Vaccine variety while [DOI] 10.3389/fimmu.2022.999233 PMC 바로가기
Constructing custom-made radiotranscriptomic signatures of vascular inflammation from routine CT angiograms: a prospective outcomes validation study in COVID-19Research article Published on 2022-10-012022-10-05 Journal: International Journal of Environmental Research an [Category] COVID19(2023년), SARS, 바이오마커, 변종, 유전자 메커니즘, 임상, 진단, 치료기술, [키워드] 95% CI Activation adjusted adjusted odds ratio aggregation Alpha Analysis application B.1.1.7 Bath biochemical Biomarkers biomarkers of inflammation biopsy changes clinical factors clinical outcomes clinically Coagulation Cohort Complication correlation Council COVID-19 death develop Dexamethasone diagnostic Direct driving dysregulation of coagulation Engineering evaluated facilitate finding foundation funding hazard ratio heart hospital identify in-hospital mortality indicated Inflammation investigated mammary marker myocardial injury National Health Service NHS NIHR Non-invasive outcome Oxford parameters Pathways Patient patients with COVID-19 perivascular Platelet platform predict produced Prognostic value pulmonary angiography pulmonary CT representing respond responsible risk RNA sequencing data SARS-CoV-2 variant Science sensitivity analysis targeted therapy therapeutic target transcriptional transcriptomic Treatment Trial validation study variant vascular inflammation Wellcome Trust Whole blood wild-type SARS-CoV-2 with COVID-19 [DOI] 10.1016/S2589-7500(22)00132-7 [Article Type] Research article
Analysis of transcriptomic responses to SARS-CoV-2 reveals plausible defective pathways responsible for increased susceptibility to infection and complications and helps to develop fast-track repositioning of drugs against COVID-19Research article Published on 2022-10-012022-10-05 Journal: Computers in biology and medicine [Category] COVID19(2023년), SARS, 바이오마커, 신약개발, 유전자 메커니즘, 진단, 치료제, [키워드] acute respiratory distress Affect Algorithm Analysis antiviral therapy Brain causes clinical study Col1a1 collagen Comorbidities Complication complications component Control coronavirus COVID-19 COVID-19 patients develop diagnostic drug drug repositioning FDA approved drug Genetic help immune system independent Infection Inflammation Inflammatory response Influenza involved kidneys Lungs machine learning methodology offer other organ pathway Pathways Patient performed principal Regulation response responsible Result reveal RSV SARS-CoV-2 SARS-COV-2 infection severity Side effect Side effects Small scale genetic signature susceptibility syndrome the disease the interferon Transcriptome transcriptomic transcriptomic analysis transcriptomic data virus replication [DOI] 10.1016/j.compbiomed.2022.106029 [Article Type] Research article
A Bioinformatic Approach Based on Systems Biology to Determine the Effects of SARS-CoV-2 Infection in Patients with Hypertrophic CardiomyopathyArticle Published on 2022-09-272022-11-15 Journal: Computational and Mathematical Methods in Medicine [Category] SARS, 바이오마커, [키워드] acute respiratory syndrome Affect Analysis analysis Bioinformatic Biology Biomarker Cardiomyopathy cardiovascular system Combination conducted coronavirus coronavirus disease COVID-19 COVID-19 progression datasets DEGs differentially expressed gene disorder drug drug candidates Effect functional Gene Expression Omnibus Genes Genetic GSE147507 identify individual knowledge Lungs microRNA mortality rate; ontology terms other organs patients with COVID-19 protein-protein interaction Proteins Research RNA SARS-CoV-2 Sequencing shared pathway shown statistical Support System therapy transcription factors transcriptomic while [DOI] 10.1155/2022/5337380 PMC 바로가기
The Variation of Transcriptomic Perturbations is Associated with the Development and Progression of Various DiseasesArticle Published on 2022-09-262022-11-16 Journal: Disease Markers [Category] 유전자 메커니즘, [키워드] activities AIDS AIDS patient Algorithm analyzed applied association atrophic gastritis cardiovascular diseases caused cellular chronic obstructive clinical implication clinically controls COPD correlated correlation COVID-19 patient deficiency defined development digestive disease Disease diagnosis Disease progression Diseases Ejection fraction Endocrine diseases expiratory expression greater Health status heterogeneity ICU immune Infection intensive care investigated involved Kidney diseases liver diseases LVEF malaria mechanical ventilatory support negative correlation Neurological disorders non-ICU patients pathway patients Perturbation presymptomatic Prognosis pulmonary disease pulmonary tuberculosis Regulation respiratory diseases severity significantly syndrome the disease Therapies transcriptome datasets transcriptomic transcriptomic data treated upregulated upregulation Variation variety ventricular Viral load Volume [DOI] 10.1155/2022/2148627 PMC 바로가기
Single-cell sequencing of PBMC characterizes the altered transcriptomic landscape of classical monocytes in BNT162b2-induced myocarditisArticle Published on 2022-09-262022-11-15 Journal: Frontiers in Immunology [Category] SARS, 유전자 메커니즘, 진단, [키워드] acute respiratory syndrome Affect Analysis AP-1 Biomarker BNT162b2 cell cluster changes changes in classical monocyte conditions conducted coronavirus Coronavirus - COVID-19 determine develop disease downregulation fatty acid metabolism Gene Expression identify include infiltration Kawasaki disease monocyte monocyte - macrophage Monocytes mononuclear cell mRNA vaccine myocarditis Pathogenesis Patient PBMC Peripheral blood proceed provides public health RNA RNA sequence SARS-CoV-2 SARS-COV-2 infection Sequencing single-cell Single-cell RNA sequencing subject the disease transcription factor Transcriptome transcriptome (RNA-seq) transcriptomic transcriptomic profile upregulation vaccination vaccination. [DOI] 10.3389/fimmu.2022.979188 PMC 바로가기